Tailored cytomegalovirus can help T cells detect more SIV


According to a new study, a designed cytomegalovirus (CMV) has fundamentally changed the activity of T cells to protect rhesus monkeys from SIV infection; SIV in monkeys is equivalent to human HIV.

Scott Hansen and colleagues have recently reported a CMV strain designed to express certain SIV proteins, so that vaccinated monkeys can control SIV infection. Now they report that this particular vaccine vector will drive A very unique immune response from CD8 + T cells. They said that when they met the designed CMV strain called 68-1 RhCMV, CD8 + T cells would initiate a much stronger response than their usual immune response to SIV. In the presence of 68-1 RhCMV, CD8 + T cells can target the epitope of SIV—or a small fragment of an antigenic protein—and these antigenic epitopes usually avoid Designed viral vectors or immune responses stimulated only by SIV infection. According to the researchers, CD8 + T cells usually only respond to antigens presented by cells belonging to the major histocompatibility complex of class I-or MHC-I, but 68-1 RhCMV produces anti-MHC-I CD8 + T cells react with MHC-II molecules.

Their results show that CMV vectors can affect CD8 + T cells by genetic programming so that they can recognize a wider range of SIV epitopes. These findings may eventually lead to more effective treatments for HIV, and a "Viewpoint" article by Nilu Goonetilleke and Andrew McMichael explains these results in more detail.

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Magnetic Receptive Whiteboard Sheet is one kind of flexible whiteboard. It is easy cut, bent, twisted, coiled, or can machined into almost any shape. So it can be roll up to saving space and carry easily.

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